Mitochondrial metabolites extend lifespan

Mitochondrial metabolites extend lifespan

Disruption of mitochondrial respiration in the nematode Caenorhabditis elegans can extend lifespan. We previously showed that long-lived respiratory mutants generate elevated amounts of α-ketoacids. These compounds are structurally related to α-ketoglutarate, suggesting they may be biologically relevant. Here, we show that provision of several such metabolites to wild-type worms is sufficient t...

Can oxygen anosmia extend lifespan?

Antimicrobial peptides extend lifespan in Drosophila

Antimicrobial peptides (AMPs) are important defense molecules of the innate immune system. High levels of AMPs are induced in response to infections to fight pathogens, whereas moderate levels induced by metabolic stress are thought to shape commensal microbial communities at barrier tissues. We expressed single AMPs in adult flies either ubiquitously or in the gut by using the inducible GeneSw...

Rapamycin Doses Sufficient to Extend Lifespan Do Not Compromise Muscle Mitochondrial Content or Endurance

Citation Ye, Lan, et al. "Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance." The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters.

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately limit its utility in humans. The canonical target of rapamycin, and the one thought to account for its effects on lifespan, is the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). We have previously shown that at least some of the detrimental side effects of rapamycin are due to "o...